Fecal transplant via retention enema for refractory or recurrent Clostridium difficile infection.
نویسندگان
چکیده
Published Online: November 28, 2011. doi:10.1001 /archinternmed.2011.548 AuthorAffiliations:DivisionofVascularSurgery(DrsSano, Unno, Yamamoto, and Tanaka), and Second Department of Surgery (Drs Sano, Unno, Yamamoto, Tanaka, and Konno),HamamatsuUniversitySchoolofMedicine,Hamamatsu, Japan. Correspondence: Dr Unno, Division of Vascular Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan ([email protected]). AuthorContributions:DrUnnohad full access toall of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Sano, Unno, and Yamamoto. Acquisition of data: Sano, Yamamoto, and Tanaka. Analysis and interpretationofdata:Sano,Unno,Yamamoto,Tanaka, andKonno. Drafting of the manuscript: Sano and Unno. Critical revision of themanuscript for important intellectualcontent:Unno,Yamamoto,Tanaka, andKonno. Statistical analysis: Sanoand Unno.Administrative, technical,andmaterial support:Unno, Yamamoto,andTanaka.Studysupervision:UnnoandKonno. Financial Disclosure: None reported. Funding/Support: We acknowledge the cooperation and support of the staff in the Second Department of Surgery, Hamamatsu University School of Medicine. They did not receive additional compensation for their contributions. Online-Only Material: The eTable is available at http: //www.archinternmed.com.
منابع مشابه
Clostridium difficile Infection and Fecal Microbiota Transplant.
Clostridium difficile infection (CDI) is a major source of morbidity and mortality for hospitalized patients. Although most patients have a clinical response to existing antimicrobial therapies, recurrent infection develops in up to 30% of patients. Fecal microbiota transplant is a novel approach to this complex problem, with an efficacy rate of nearly 90% in the setting of multiple recurrent C...
متن کاملFecal microbiota transplant to treat recurrent Clostridium difficile infections.
The prevalence of recurrent or refractory Clostridium difficile infection has been steadily increasing since 2000. Consequently, alternative treatments to the standard antibiotic therapies are now being considered. One alternative treatment is fecal microbiota transplant. Although fecal microbiota transplant is relatively new--and not appealing to most people--it has been around for many years ...
متن کاملFrozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.
IMPORTANCE Clostridium difficile infection (CDI) is a major burden in health care and community settings. CDI recurrence is of particular concern because of limited treatment options and associated clinical and infection control issues. Fecal microbiota transplantation (FMT) is a promising, but not readily available, intervention. OBJECTIVE To determine whether frozen-and-thawed (frozen, expe...
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Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient
The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes are poor. Fecal microbiota transplantation is becoming increasingly accepted as an effective and safe intervention in patients with recurrent disease, likely due t...
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ورودعنوان ژورنال:
- Archives of internal medicine
دوره 172 2 شماره
صفحات -
تاریخ انتشار 2012